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Magnetization transfer-based 3D visualization of foot peripheral nerves.

Ralf Mekle1, Benedicte Mortamet, Cristina Granziera

  • 1Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. ralf.mekle@gmail.com

Journal of Magnetic Resonance Imaging : JMRI
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Summary

Magnetization transfer (MT) effects offer a novel contrast source for imaging peripheral foot nerves. This technique enables high-resolution tracking of nerves, with potential applications in conditions like diabetes.

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Area of Science:

  • Magnetic Resonance Imaging
  • Neuroimaging
  • Biophysics

Background:

  • Peripheral nerve imaging is crucial for diagnosing neurological disorders.
  • Current MRI techniques face challenges in visualizing small peripheral nerves with high resolution.

Purpose of the Study:

  • To explore magnetization transfer (MT) effects as a novel contrast mechanism for peripheral foot nerve imaging and tracking.
  • To assess the feasibility of MT ratio (MTR) mapping for differentiating nerves from surrounding tissues.

Main Methods:

  • Acquisition of 3D spoiled gradient-echo images with and without a saturation pulse at 3T.
  • Generation of high-resolution (260 μm in-plane) MT ratio (MTR) maps.
  • Optimization of scan parameters to minimize signal loss and improve signal-to-noise ratio for small voxels.

Main Results:

  • Significantly different MTR values were observed between foot nerves (21.4 ± 3.1%) and surrounding muscle (45.5 ± 1.4%).
  • The distinct MTR values enabled intensity-based segmentation and tracking of individual foot nerves.
  • A novel MT-based 3D visualization technique was demonstrated.

Conclusions:

  • MT effects provide a new source of contrast for peripheral foot nerve imaging.
  • The MTR-based approach allows for high-resolution tracking of nerve structures.
  • This methodology is applicable to standard clinical MRI scanners and may aid in diagnosing systemic pathologies like diabetes.