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Related Experiment Video

Updated: May 18, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Oxycodone overdose causes naloxone responsive coma and QT prolongation.

I Berling¹, I M Whyte, G K Isbister

¹Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Waratah, NSW, Australia.

QJM : Monthly Journal of the Association of Physicians

|October 2, 2012

Summary

Oxycodone overdose can cause central nervous system depression, bradycardia, and QT prolongation. Sustained-release oxycodone overdose is linked to increased naloxone use and longer hospital stays.

Related Experiment Videos

Last Updated: May 18, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Area of Science:

Clinical Toxicology
Pharmacology
Emergency Medicine

Background:

Limited data exist on oxycodone overdose effects.
Oxycodone may cause QT prolongation beyond CNS depression.
High prescription rates necessitate understanding overdose effects.

Purpose of the Study:

Investigate clinical features of oxycodone overdose.
Analyze electrocardiogram (ECG) parameters in overdose.
Evaluate treatment strategies for oxycodone overdose.

Main Methods:

Retrospective review of a toxicology unit clinical database.
Analysis of 137 oxycodone overdose admissions (2001-2011).
Extracted data included demographics, ingestion details, clinical effects, ECG parameters (HR, QT, QRS), naloxone use, and length of stay (LOS).

Main Results:

137 overdoses analyzed; 58% ingested immediate-release (IR), 42% sustained-release (SR).
Bradycardia occurred in 18% of patients; 17% had abnormal QT-HR pairs.
Sustained-release oxycodone was associated with higher naloxone use and longer LOS (36 hours for naloxone infusion patients).

Conclusions:

Oxycodone overdose causes CNS depression, bradycardia, and QT prolongation.
Sustained-release formulations correlate with increased naloxone requirements and prolonged hospital stays.
Understanding these effects is crucial for managing oxycodone toxicity.