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Related Experiment Video

Updated: May 18, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Diffuse large B-cell lymphoma presenting with extensive cutaneous infiltration.

Norashikin Shamsudin¹, Choong Chor Chang

¹Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia. aliffarhan@yahoo.com

Singapore Medical Journal

|October 2, 2012

Summary

This case study details a systemic diffuse large B-cell lymphoma (DLBCL) that extensively infiltrated the skin. Chemotherapy effectively treated the patient, leading to the resolution of skin lesions and systemic symptoms.

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Last Updated: May 18, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Area of Science:

Oncology
Dermatology
Hematology

Background:

Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin's lymphoma.
Skin involvement in DLBCL can manifest in various ways, sometimes preceding systemic diagnosis.
Early recognition of cutaneous manifestations is crucial for timely diagnosis and treatment.

Observation:

A 56-year-old woman presented with a two-month history of pruritic, erythematous plaques and nodules on her skin.
Clinical examination revealed hepatosplenomegaly, lymphadenopathy, and constitutional symptoms including night sweats and weight loss.
Laboratory findings included pancytopenia and elevated lactate dehydrogenase (LDH).

Findings:

Skin biopsy confirmed diffuse sheets of CD20 and CD79a positive neoplastic cells, indicative of DLBCL.
Computed tomography (CT) showed widespread lymphadenopathy.
Bone marrow biopsy confirmed bone marrow involvement by lymphoma.

Implications:

This case highlights the importance of considering DLBCL in patients with extensive cutaneous lesions and systemic symptoms.
Prompt diagnosis through skin biopsy and staging investigations is essential for effective management.
Chemotherapy demonstrated efficacy in achieving remission of both cutaneous and systemic disease.