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Acute exacerbation of COPD is associated with fourfold elevation of cardiac troponin T

Vidar Søyseth1, Rahul Bhatnagar, Nils Henrik Holmedahl

  • 1Department of Medicine, Akershus University Hospital, University of Oslo, Sykehusvn 25, Lørenskog 1478, Norway. vidar.soyseth@medisin.uio.no

Heart (British Cardiac Society)
|October 2, 2012
PubMed

Insights

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is linked to higher cardiac troponin levels, indicating myocardial injury. Determinants of troponin levels differ between stable COPD and AECOPD patients.

Area of Science:

  • Cardiology
  • Pulmonology
  • Biomarkers

Background:

  • Chronic obstructive pulmonary disease (COPD) is a progressive lung disease.
  • Acute exacerbations of COPD (AECOPD) are common and associated with significant morbidity.
  • Myocardial injury, indicated by elevated high-sensitivity cardiac troponin T (hs-cTnT), may occur during AECOPD.

Purpose of the Study:

  • To investigate the association between AECOPD and elevated hs-cTnT.
  • To identify factors associated with hs-cTnT levels in COPD patients during stable states and exacerbations.

Main Methods:

  • Cross-sectional study comparing hs-cTnT levels in hospitalized AECOPD patients versus stable COPD patients.
  • Data collected from consecutive admissions at teaching and pulmonary rehabilitation clinics (2010-2011).
  • Multiple linear regression analyses used to identify determinants of hs-cTnT.

Main Results:

  • AECOPD patients exhibited significantly higher hs-cTnT levels (geometric mean 25.8 ng/l) compared to stable COPD patients (4.55 ng/l).
  • In stable COPD, hs-cTnT levels positively correlated with leucocyte count, pathological q-waves, electrocardiographic left ventricular hypertrophy, long-term oxygen therapy, and reduced FEV1.
  • No significant determinants of hs-cTnT were identified in AECOPD patients.

Conclusions:

  • AECOPD is associated with increased hs-cTnT, suggesting myocardial injury.
  • In stable COPD, hs-cTnT levels are influenced by COPD severity markers.
  • The factors influencing hs-cTnT levels in AECOPD remain unclear.
Abstract

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