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Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC

Jayanta Gupta1, Nandita Mitra, Peter A Kanetsky

  • 1University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

Clinical Journal of the American Society of Nephrology : CJASN
|October 2, 2012
PubMed

Insights

Inflammation biomarkers are linked to poorer kidney function and increased albuminuria in Chronic Kidney Disease (CKD) patients. Lower estimated Glomerular Filtration Rate (eGFR) and higher albuminuria correlate with higher inflammation markers.

Area of Science:

  • Nephrology
  • Immunology
  • Biomarker Research

Background:

  • Chronic Kidney Disease (CKD) is associated with increased mortality, often attributed to inflammation.
  • The relationship between kidney function, albuminuria, and inflammation biomarkers in a large CKD cohort remains understudied.

Purpose of the Study:

  • To investigate the association between kidney function, albuminuria, and various inflammation biomarkers in a large cohort of CKD patients.
  • To establish an inflammation score and assess its relationship with kidney function and albuminuria.

Main Methods:

  • Plasma levels of inflammatory markers (IL-1β, IL-1RA, IL-6, TNF-α, hs-CRP, fibrinogen) and serum albumin were measured in 3939 CKD participants.
  • An inflammation score was calculated using key inflammatory markers.
  • Kidney function was assessed by estimated Glomerular Filtration Rate (eGFR) and serum cystatin C; albuminuria was measured by urine albumin to creatinine ratio (UACR).

Main Results:

  • Lower eGFR and higher UACR were associated with higher levels of most inflammation biomarkers and the overall inflammation score.
  • eGFR, cystatin C, and UACR were significantly associated with fibrinogen, serum albumin, IL-6, and TNF-α.
  • Increased eGFR and cystatin C were linked to decreased IL-6, while increased UACR was linked to increased IL-6.

Conclusions:

  • Biomarkers of inflammation show an inverse association with measures of kidney function (eGFR, cystatin C).
  • Inflammation biomarkers are positively associated with albuminuria (UACR).
  • These findings highlight the interplay between inflammation and kidney disease progression.
Abstract

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