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Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

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Subcutaneous human dirofilariasis.

Elizabeth Joseph1, Anna Matthai, Latha K Abraham

  • 1Department of Pathology, Malankara Orthodox Syrian Church Medical College, Kolenchery, Ernakulam District, Kerala 682 311 India ; Department of Pathology, Al Sabah Hospital, Post Box 4078, Safat, 13041 Kuwait.

Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology
|October 2, 2012
PubMed
Summary
This summary is machine-generated.

Subcutaneous dirofilariasis, caused by Dirofilaria repens, is an emerging zoonosis. Diagnosis requires examining deeper tissue levels in suspected parasitic granuloma cases, as peripheral eosinophilia is absent.

Keywords:
Abdominal wallChestFaceHuman dirofilariasisScrotumSubcutaneous

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Area of Science:

  • Medical Parasitology
  • Zoonotic Diseases
  • Dermatology

Background:

  • Subcutaneous dirofilariasis is a zoonotic parasitic infection caused by Dirofilaria repens.
  • The incidence of reported cases is increasing, suggesting it as an emerging zoonosis.
  • Clinical presentation can mimic neoplastic or inflammatory lesions.

Purpose of the Study:

  • To report a series of 21 cases of subcutaneous dirofilariasis.
  • To highlight diagnostic challenges and emphasize optimal diagnostic methods.
  • To underscore the significance of Dirofilaria repens as an emerging public health concern.

Main Methods:

  • Retrospective analysis of 21 cases diagnosed with subcutaneous dirofilariasis over 8 years.
  • Clinical and histopathological evaluation of subcutaneous nodules.
  • Emphasis on deep tissue sectioning for parasite identification.

Main Results:

  • Twenty-one cases of subcutaneous dirofilariasis were identified.
  • None of the patients exhibited peripheral eosinophilia.
  • Parasitic granulomas were confirmed through histopathological examination of deeper tissue levels.

Conclusions:

  • Subcutaneous dirofilariasis is an emerging zoonosis that does not typically present with peripheral eosinophilia.
  • It is crucial to consider dirofilariasis in the differential diagnosis of subcutaneous nodules, especially in endemic regions.
  • Thorough histopathological examination of multiple deeper tissue levels is essential for accurate diagnosis of parasitic granuloma.