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Conducting Hyperscanning Experiments with Functional Near-Infrared Spectroscopy

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Spectral domain detection in low-coherence spectroscopy.

Nienke Bosschaart¹, Maurice C G Aalders, Ton G van Leeuwen

¹Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, P.O. Box 22700, NL-1100 DE Amsterdam, The Netherlands.

Biomedical Optics Express

|October 2, 2012

Summary

Spectral domain detection in low-coherence spectroscopy (sdLCS) offers improved speed and sensitivity for measuring tissue optical properties. This new method was validated computationally and experimentally, showing accurate results for attenuation, absorption, and scattering coefficients.

Keywords:

(030.1640) Coherence (160.4760) Optical properties (170.6510) Spectroscopy, tissue diagnostics (300.6190) Spectrometers

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Published on: October 11, 2016

Area of Science:

Biomedical Optics
Spectroscopy
Tissue Optics

Background:

Low-coherence spectroscopy (LCS) enables quantitative, wavelength-resolved optical property measurements within defined tissue volumes.
Current LCS methods primarily use time-domain detection (tdLCS).
Spectral domain detection (sdLCS) offers theoretical advantages in speed and sensitivity over tdLCS.

Purpose of the Study:

Introduce and validate a novel spectral domain detection method for LCS (sdLCS).
Optimize sdLCS sensitivity as a function of measurement depth.
Compare sdLCS performance against established tdLCS methods.

Main Methods:

Developed a spectral domain detection system for low-coherence spectroscopy.
Validated the sdLCS method using computational simulations.
Experimentally verified the sdLCS method on a phantom with known optical properties.

Main Results:

The sdLCS method achieved optimal sensitivity dependent on measurement depth.
Computational simulations confirmed the method's validity.
Experimental results on a phantom showed good agreement between sdLCS measurements and expected optical properties.
sdLCS measurements correlated well with those obtained using tdLCS.

Conclusions:

The developed sdLCS method provides accurate quantitative measurement of tissue optical properties.
sdLCS demonstrates a viable and advantageous alternative to tdLCS for optical property characterization.
This technique holds potential for advancing non-invasive tissue diagnostics and research.