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A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
Published on: January 5, 2024
Pediatric fibromyalgia
Insights
Fibromyalgia (FM) is a chronic pain condition impacting adults and children, characterized by widespread pain and fatigue. Management focuses on education, cognitive changes, and physical exercise, with limited medication use.
Area of Science:
- Rheumatology
- Pain Medicine
- Pediatric Rheumatology
Background:
- Fibromyalgia (FM) is defined by chronic widespread pain (CWP) and heightened sensitivity to pressure.
- FM presents with significant fatigue, sleep disturbances, bowel issues, and neuropsychiatric symptoms like anxiety and cognitive dysfunction.
- The exact cause of FM is unknown but is thought to involve central nervous system (CNS) dysfunction affecting pain processing.
Purpose of the Study:
- To provide a comprehensive overview of Fibromyalgia Syndrome (FMS), including its definition, associated symptoms, and pathogenesis.
- To highlight the specific challenges and considerations in diagnosing and managing pediatric FMS.
- To differentiate pediatric FMS from other inflammatory joint disorders in children.
Main Methods:
- Literature review and synthesis of current understanding regarding FM definition, symptoms, and pathophysiology.
- Analysis of diagnostic criteria and differential diagnoses for pediatric FMS.
- Review of established and emerging management strategies for pediatric FMS.
Main Results:
- FM is characterized by CWP, allodynia, fatigue, sleep, and cognitive issues, linked to CNS malfunction.
- Pediatric FMS affects children and adolescents, requiring differentiation from conditions like juvenile idiopathic arthritis (JIA).
- Management of pediatric FMS prioritizes education, behavioral/cognitive therapy, and physical exercise over pharmacotherapy.
Conclusions:
- Fibromyalgia is a complex syndrome with diverse symptoms impacting quality of life.
- Pediatric FMS presents unique challenges in diagnosis and management during critical developmental stages.
- A multidisciplinary approach emphasizing non-pharmacological interventions is key for managing pediatric FMS effectively.
Abstract:
Fibromyalgia (FM) is currently defined as chronic widespread pain (CWP) with allodynia or hyperalgesia to pressure pain. It is classified as one of the large group of soft-tissue pain syndromes. Pain is the cardinal symptom of FM; however, most patients also experience additional symptoms such as debilitating fatigue, disrupted or non-restorative sleep, functional bowel disturbances, and a variety of neuropsychiatric problems, including cognitive dysfunction, anxiety and depressive symptoms. Its pathogenesis is not entirely understood, although it is currently believed to be the result of a central nervous system (CNS) malfunction that increases pain transmission and perception. FMS usually involves females, and in these patients it often makes its first appearance during menopause. But it is often diagnosed both in young as well as elderly individuals. Pediatric FMS is a frustrating condition affecting children and adolescents at a crucial stage of their physical and emotional development. Pediatric FMS is an important differential diagnosis to be considered in the evaluation of children suffering from widespread musculoskeletal pain, and must be differentiated from a spectrum of inflammatory joint disorders such as juvenile idiopathic arthritis (JIA), juvenile ankylosing spondylitis, etc. The management of pediatric FMS is centered on the issues of education, behavioral and cognitive change (with a strong emphasis on physical exercise), and a relatively minor role for pharmacological treatment with medications such as muscle relaxants, analgesics and tricyclic agents.
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