Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex and gender differences in comorbidities in spondyloarthritis: a focus on psoriatic arthritis.

Reumatismo·2024
Same author

Role of micronutrients in the symptoms of fibromyalgia: a review of the literature and analysis of an Italian female sample.

European review for medical and pharmacological sciences·2024
Same author

Retention rate of abatacept in rheumatoid arthritis patients in a real-life setting: results from a monocentric cohort.

Reumatismo·2024
Same author

Anti-tumor necrosis factor α: originators <i>versus</i> biosimilars, comparison in clinical response assessment in a multicenter cohort of patients with inflammatory arthropathies.

Reumatismo·2023
Same author

The Italian Society for Rheumatology clinical practice guidelines for the diagnosis and management of fibromyalgia Best practices based on current scientific evidence.

Reumatismo·2021
Same author

Domestic violence detection amid the COVID-19 pandemic: the value of the WHO questionnaire in emergency medicine.

QJM : monthly journal of the Association of Physicians·2020
Same journal

Delayed referral, socioeconomic status, and disease characteristics as factors associated with disabilities in rheumatoid arthritis patients: a multicenter observational study.

Reumatismo·2026
Same journal

Telerheumatology to improve first access outcomes in outpatients: a prospective monocentric pilot study.

Reumatismo·2026
Same journal

Hypocomplementemic urticarial vasculitis: a rare presentation revealing systemic lupus erythematosus and Sjögren's disease.

Reumatismo·2026
Same journal

Is there still someone laughing at Christopher Columbus?

Reumatismo·2026
Same journal

Concurrent herpetic hypertensive anterior uveitis and cytomegalovirus retinitis in a non-HIV patient with melanoma differentiation-associated gene-5 dermatomyositis: intravenous immunoglobulin comes to the rescue.

Reumatismo·2026
Same journal

Myasthenic syndrome in systemic lupus erythematosus successfully treated with plasma exchange: through one of the unexplored faces of neuropsychiatric involvement.

Reumatismo·2026
See all related articles

Related Experiment Video

Updated: May 18, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Fibromyalgia and arthritides.

F Atzeni1, S Sallì, M Benucci

  • 1Rheumatology Unit, L. Sacco University Hospital of Milan, Italy.

Reumatismo
|October 2, 2012
PubMed
Summary
This summary is machine-generated.

Fibromyalgia (FM) is a chronic pain condition affecting 2% of adults, characterized by widespread pain and fatigue. Understanding central nervous system involvement and differentiating primary from secondary FM is crucial for effective patient management.

More Related Videos

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

Related Experiment Videos

Last Updated: May 18, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

Area of Science:

  • Rheumatology
  • Neuroscience
  • Pain Medicine

Background:

  • Fibromyalgia (FM) is a prevalent chronic pain syndrome impacting at least 2% of adults.
  • FM is characterized by widespread pain, fatigue, sleep disturbances, and distress, often linked to central nervous system (CNS) dysfunction.
  • FM frequently co-occurs with conditions like rheumatoid arthritis (RA), spondyloarthritides (SpA), osteoarthritis (OA), and thyroid disease, complicating diagnosis and management.

Purpose of the Study:

  • To highlight the importance of understanding central nervous system (CNS) mechanisms in fibromyalgia (FM).
  • To emphasize the need for rheumatologists to differentiate between primary and secondary FM.
  • To advocate for improved diagnostic guidelines and tools for managing FM, particularly when co-occurring with arthritic conditions.

Main Methods:

  • Review of current understanding of FM pathophysiology, focusing on CNS involvement.
  • Analysis of the impact of comorbidities on FM presentation and management.
  • Discussion of clinical challenges in distinguishing primary vs. secondary FM.

Main Results:

  • Emerging evidence points to CNS malfunction as a key factor in increased pain transmission and perception in FM.
  • Associated conditions can confound and aggravate FM symptoms, impacting overall patient well-being.
  • Accurate differentiation between primary and secondary FM is essential for appropriate treatment.

Conclusions:

  • Effective FM management requires a mechanism-based approach addressing both peripheral and central pain pathways.
  • Rheumatologists require enhanced guidelines and instruments to accurately diagnose and manage FM, especially in patients with comorbidities.
  • Addressing diffuse pain in arthritic patients with FM is critical to improving their quality of life.