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Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Related Experiment Video

Updated: May 18, 2026

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Published on: February 17, 2019

Spinal intradural teratomas: developmental programs gone awry?

M Yashar S Kalani¹, Sudarshan Iyer, Stephen W Coons

¹Division of Neurological Surgery, Barrow Neurological Institute, Phoenix, AZ, USA.

Neurosurgical Focus

|October 3, 2012

Summary

Spinal intradural teratomas are rare pediatric tumors. This case highlights their dysembryogenic origin, potentially linked to early embryonic developmental defects.

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Last Updated: May 18, 2026

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

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Published on: February 17, 2019

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Fate Mapping of Human Embryonic Stem Cells by Teratoma Formation

Fate Mapping of Human Embryonic Stem Cells by Teratoma Formation

Published on: August 1, 2010

Area of Science:

Neuro-oncology
Developmental Biology
Embryology

Background:

Intradural spinal teratomas are uncommon pediatric neoplasms.
Their precise etiology remains largely unknown.
Current hypotheses suggest a dysembryogenic origin during embryonic development.

Observation:

A case of spinal intradural teratoma in an 18-year-old male is presented.
The patient was previously healthy, with no prior significant medical history.
The tumor was located intradurally within the spinal cord.

Findings:

The development of spinal teratomas is linked to defects in neurulation.
Embryogenesis errors are implicated in the formation of these tumors.
This case adds to the literature on spinal teratomas in young adults.

Implications:

Understanding the embryogenic basis can inform future research into spinal tumor development.
Early detection and diagnosis of spinal teratomas are crucial for patient outcomes.
Further investigation into neurulation defects may reveal novel therapeutic targets.