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Enzyme-responsive polymeric supra-amphiphiles formed by the complexation of chitosan and ATP
Yuetong Kang1, Chao Wang, Kai Liu
1Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China.
Abstract:
Chitosan and adenosine-5'-triphosphate (ATP) are employed as building blocks to fabricate polymeric supra-amphiphiles based on electrostatic interactions, which can self-assemble to form spherical aggregates. The spherical aggregates inherit the phosphotase responsiveness of ATP. Compared to our previous work, this enzyme-responsive system can be more biocompatible and block polymers are not needed in preparation, which makes it possible to fabricate the chitosan-based enzyme-responsive assemblies in a large-scale, cheap way. Therefore, the application of the assemblies for nanocontainers and drug delivery is greatly anticipated.
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