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Gangliosides improve synaptic transmission in dentate gyrus of hippocampal rat slices
O A Ramirez1, R A Gomez, H F Carrer
1Departmento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Argentina.
Brain Research
|January 8, 1990
Abstract:
The effect of perfusion with gangliosides (1 x 10(-6) M) on the response evoked in the granule cell layer of dentate gyrus by stimulation of perforant path in hippocampal rat slices was studied. Gangliosides induced both a decrease in the frequency threshold of stimulation necessary to generate long-term potentiation (LTP) and greater potentiation than under control conditions. It is proposed that gangliosides improve the mechanisms responsible for synaptic plasticity which generate LTP.