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Updated: May 18, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
The independent association of hypertension with cognitive function among older adults with heart failure
Michael L Alosco1, Adam M Brickman, Mary Beth Spitznagel
1Department of Psychology, Kent State University, Kent, OH, USA. Malosco@kent.edu
Insights
Hypertension significantly impacts cognitive function in heart failure patients, particularly affecting attention and motor skills. This highlights the need to manage blood pressure for better brain health in this population.
Area of Science:
- Cardiology
- Neurology
- Gerontology
Background:
- Hypertension is a common comorbidity in heart failure (HF) patients.
- Cognitive impairment is prevalent in HF, but hypertension's specific role is unclear.
Purpose of the Study:
- To investigate the association between hypertension and cognitive function in heart failure patients.
Main Methods:
- 116 HF patients underwent neuropsychological testing and impedance cardiography.
- Hypertension history was confirmed via medical chart review.
- Adjustments were made for demographic and medical factors.
Main Results:
- 69.8% of HF patients had a history of hypertension.
- Hypertension independently associated with poorer attention, executive function, psychomotor speed, and motor functioning.
- HF patients with hypertension performed worse in these cognitive domains.
Conclusions:
- Hypertension history is a significant contributor to cognitive impairment in HF.
- Further research should explore hypertension's impact on cerebral autoregulation and brain damage in HF.
Objective:
Hypertension is the most common comorbidity among heart failure (HF) patients and has been independently linked with cognitive impairment. Cognitive impairment is prevalent among HF patients, though the extent to which hypertension contributes to cognitive function in this population is unclear.
Methods:
116 HF patients (31.0% women, 67.68 ± 11.16 years) completed neuropsychological testing and impedance cardiography. History of physician diagnosed hypertension, along with other medical characteristics, was ascertained through a review of participants' medical charts.
Results:
69.8% of the HF patients had a diagnostic history of hypertension. After adjustment for demographic and medical characteristics (i.e., cardiac index, medication status, and resting blood pressure), hypertension was independently associated with attention/executive function/psychomotor speed (ΔF(1,103)=10.85, ΔR(2)=.07, p<.01) and motor functioning (ΔF(1,103)=4.46, ΔR(2)=.04, p<.05). HF patients with a diagnosed history of hypertension performed worse in these domains than those without such history.
Conclusion:
The current findings indicate that diagnostic history of hypertension is an important contributor to cognitive impairment in HF. Hypertension frequently precedes HF and future studies should examine whether sustained hypertension compromises cerebral autoregulatory mechanisms to produce brain damage and exacerbate cognitive impairment in this population.
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