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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

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Related Experiment Video

Updated: May 18, 2026

Extracellular Vesicle Tissue Factor Activity Assay
03:53

Extracellular Vesicle Tissue Factor Activity Assay

Published on: December 29, 2023

Tissue factor and cancer.

Wolfram Ruf1

  • 1Department of Immunology and Microbial Science, SP258, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States. ruf@scripps.edu

Thrombosis Research
|October 3, 2012
PubMed
Summary
This summary is machine-generated.

The hemostatic system, particularly tissue factor (TF), drives tumor progression and metastasis. Targeting TF-related pathways offers potential therapeutic strategies for cancer treatment.

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Extracellular Vesicle Tissue Factor Activity Assay
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Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets
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Orthotopic Injection of Breast Cancer Cells into the Mammary Fat Pad of Mice to Study Tumor Growth.
07:52

Orthotopic Injection of Breast Cancer Cells into the Mammary Fat Pad of Mice to Study Tumor Growth.

Published on: February 8, 2015

Area of Science:

  • Oncology
  • Hematology
  • Molecular Biology

Background:

  • The hemostatic system interacts with cancer cells, influencing tumor growth and spread.
  • Oncogenic transformations activate key hemostasis components like tissue factor (TF).

Purpose of the Study:

  • To elucidate the role of the hemostatic system in cancer progression and metastasis.
  • To identify molecular interactions between transformed cells and hemostasis pathways.

Main Methods:

  • Analysis of molecular interactions between cancer cells and hemostatic factors.
  • Investigation of signaling pathways involving tissue factor (TF), protease-activated receptor (PAR) 2, and factor VIIa.

Main Results:

  • Oncogenic transformation upregulates tissue factor (TF) and associated signaling molecules (PAR2, FVIIa).
  • TF-dependent signaling promotes primary tumor growth.
  • TF-initiated coagulation supports cancer metastasis.

Conclusions:

  • The hemostatic system is a critical regulator of tumor progression and metastasis.
  • Targeting TF-driven pathways presents a promising therapeutic avenue for cancer treatment.