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The mineralocorticoid signaling pathway throughout development: expression, regulation and pathophysiological
Laetitia Martinerie1, Mathilde Munier, Damien Le Menuet
1Inserm, U693, 63 rue Gabriel Péri, Le Kremlin-Bicêtre, F-94276, France.
Biochimie
|October 3, 2012
Summary
Mineralocorticoid receptor (MR) signaling is crucial for perinatal development. This review details MR regulation and expression in key organs, highlighting tissue-specific control during development.
Area of Science:
- Endocrinology
- Developmental Biology
- Molecular Biology
Background:
- The mineralocorticoid signaling pathway is implicated in various pathologies.
- Emerging evidence highlights its role in physiological processes during development of kidney, brain, heart, and lung.
Purpose of the Study:
- To describe aldosterone biosynthesis and mineralocorticoid receptor (MR) expression during the perinatal period.
- To highlight specificities in MR expression and regulation during the development of major organs.
Main Methods:
- Literature review focusing on aldosterone biosynthesis and MR expression.
- Analysis of tissue-specific MR regulation during perinatal development.
Main Results:
- Aldosterone biosynthesis and MR expression settings are described for the perinatal period.
- MR expression and regulation exhibit tissue-specific characteristics during development.
- Evidence suggests tight, tissue-specific control of MR expression during development.
Conclusions:
- Mineralocorticoid receptor (MR) expression is tightly controlled in a tissue-specific manner during perinatal development.
- Dysregulation of this control may have significant pathophysiological implications in the neonatal period.
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