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The mineralocorticoid signaling pathway throughout development: expression, regulation and pathophysiological

Laetitia Martinerie1, Mathilde Munier, Damien Le Menuet

  • 1Inserm, U693, 63 rue Gabriel Péri, Le Kremlin-Bicêtre, F-94276, France.

Biochimie
|October 3, 2012
PubMed

Insights

Mineralocorticoid receptor (MR) signaling is crucial for perinatal development. This review details MR regulation and expression in key organs, highlighting tissue-specific control during development.

Area of Science:

  • Endocrinology
  • Developmental Biology
  • Molecular Biology

Background:

  • The mineralocorticoid signaling pathway is implicated in various pathologies.
  • Emerging evidence highlights its role in physiological processes during development of kidney, brain, heart, and lung.

Purpose of the Study:

  • To describe aldosterone biosynthesis and mineralocorticoid receptor (MR) expression during the perinatal period.
  • To highlight specificities in MR expression and regulation during the development of major organs.

Main Methods:

  • Literature review focusing on aldosterone biosynthesis and MR expression.
  • Analysis of tissue-specific MR regulation during perinatal development.

Main Results:

  • Aldosterone biosynthesis and MR expression settings are described for the perinatal period.
  • MR expression and regulation exhibit tissue-specific characteristics during development.
  • Evidence suggests tight, tissue-specific control of MR expression during development.

Conclusions:

  • Mineralocorticoid receptor (MR) expression is tightly controlled in a tissue-specific manner during perinatal development.
  • Dysregulation of this control may have significant pathophysiological implications in the neonatal period.

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