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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Published on: March 14, 2017

Transition and sickle cell disease.

Michael R DeBaun1, Joseph Telfair

  • 1Department of Pediatrics, Vanderbilt University School of Medicine and Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, Tennessee 37232-9000, USA. m.debaun@vanderbilt.edu

Pediatrics
|October 3, 2012
PubMed
Summary

Transitioning adolescents with sickle cell disease (SCD) to adult care requires specialized guidelines. Addressing unique challenges like cognitive impairment and comorbid conditions is crucial for successful long-term health management.

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Area of Science:

  • Genetics and Hematology
  • Pediatric and Adult Medicine
  • Public Health

Background:

  • Sickle cell disease (SCD) is a prevalent genetic disorder, affecting approximately 1 in 2400 newborns in the US, with higher incidence in individuals of African descent.
  • Despite a low pediatric mortality rate, evidence-based guidelines for transitioning SCD patients from pediatric to adult care are lacking.
  • Adolescents with SCD face unique challenges, including higher rates of public insurance, cognitive impairment from strokes, lower high school graduation rates, and comorbidities like asthma.

Purpose of the Study:

  • To highlight the critical need for improved transition interventions for adolescents and young adults with SCD.
  • To identify key challenges unique to SCD patients during the transition to adult healthcare.
  • To emphasize the collaborative role of primary care physicians and pediatric specialists in enhancing transition care.

Main Methods:

  • Review of existing literature and clinical practices regarding SCD transition care.
  • Analysis of unique health, social, and educational factors impacting adolescents with SCD.
  • Identification of potential strategies for primary care physicians and specialists to improve transition outcomes.

Main Results:

  • Young adults with SCD are living longer, making the transition to adult primary care a critical health management step.
  • SCD patients experience specific obstacles during transition, including cognitive deficits, educational risks, and higher comorbidity burdens.
  • Current transition programs often lack specific evidence-based guidelines tailored to the needs of SCD patients.

Conclusions:

  • Enhanced transition interventions are essential for improving long-term health outcomes in young adults with SCD.
  • Collaboration between pediatric specialists and primary care physicians is key to developing effective, individualized transition plans.
  • Addressing the multifaceted challenges faced by SCD patients is vital for successful healthcare management beyond pediatric care.