Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extreme Lateral Infracondylar Approach for Occipital Artery to Vertebral Artery (V3) Bypass for Vertebrobasilar Insufficiency: 2-Dimensional Operative Video.

Operative neurosurgery (Hagerstown, Md.)·2025
Same author

Anatomical determinants of occipitocervical fusion in skull base chordoma resection: a systematic review of the literature with illustrative cases.

Neurosurgical focus·2024
Same author

A new office-based procedure for treatment of snoring: The S.I.Le.N.C.E. study.

Laryngoscope investigative otolaryngology·2020
Same author

Safety and efficacy of sphenopalatine ganglion stimulation for chronic cluster headache: a double-blind, randomised controlled trial.

The Lancet. Neurology·2019
Same author

Erratum: The Laparoscopically Harvested Omental Free Flap: A Compelling Option for Craniofacial and Cranial Base Reconstruction.

Journal of neurological surgery. Part B, Skull base·2018
Same author

Neuroradiological and Neuropathological Changes After 177Lu-Octreotate Peptide Receptor Radionuclide Therapy of Refractory Esthesioneuroblastoma.

Operative neurosurgery (Hagerstown, Md.)·2018

Related Experiment Video

Updated: May 18, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

Revising large scars.

Dara R Liotta1, Peter D Costantino, David H Hiltzik

  • 1Department of Otolaryngology, Lenox Hill Hospital, New York Head and Neck Institute, Northshore-LIJ Health System, New York, New York, USA.

Facial Plastic Surgery : FPS
|October 3, 2012
PubMed
Summary
This summary is machine-generated.

Plastic surgeons revise large head and neck scars to restore function and improve appearance. Techniques include tissue expansion, grafting, flaps, and newer methods like artificial skin and fat grafting.

Related Experiment Videos

Last Updated: May 18, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

Area of Science:

  • Plastic and Reconstructive Surgery
  • Dermatology
  • Medical Aesthetics

Background:

  • Large scars in the head and neck can cause significant patient distress.
  • Scar contracture can compromise function, necessitating surgical revision.
  • Improving scar appearance is a secondary but important goal.

Purpose of the Study:

  • To review current and emerging techniques for revising large head and neck scars.
  • To address the functional and aesthetic challenges posed by these scars.
  • To highlight advancements in scar revision surgery.

Main Methods:

  • Serial partial excision
  • Tissue expansion (intraoperative and prolonged)
  • Skin grafting (split- and full-thickness)
  • Regional flaps
  • Free microvascular tissue transfer

Main Results:

  • Established surgical techniques effectively address scar contracture and appearance.
  • Emerging methods like artificial skin and autologous fat grafting show promise for large scar revision.
  • A combination of techniques may be required for optimal outcomes.

Conclusions:

  • Effective management of large head and neck scars requires a range of surgical techniques.
  • Patient distress and functional compromise are key considerations in scar revision.
  • Ongoing research into novel materials and procedures continues to advance the field of scar revision.