Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How We Do It: Use of Mohs Paste (Zinc Chloride) for Calvarial Outer Table Removal in Advanced Cutaneous Malignancy.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2025
Same author

Mohs versus wide local excision: Highlighting the need to define optimal surgical strategies for hidradenocarcinoma.

JAAD case reports·2025
Same author

The Surgical Management of Cutaneous Melanoma.

Dermatologic clinics·2025
Same author

Neurotropism detected during Mohs micrographic surgery for melanoma in situ.

JAAD case reports·2024
Same author

5-Year Follow-Up of a Physician Performance Feedback Report Intervention to Reduce Overuse and Excess Cost: A National Cohort Study.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2024
Same author

Dermal MART-1-Positive Proliferations Encountered on Mohs Sections During Melanoma Treatment.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2023
Same journal

In-Office Surgical Procedures for Prejuvenation.

Facial plastic surgery : FPS·2026
Same journal

Platelet-Rich Plasma and Platelet-Rich Fibrin in Facial Plastic Surgery: A Comprehensive Literature Review.

Facial plastic surgery : FPS·2026
Same journal

Neck Contouring Prejuvenation Techniques.

Facial plastic surgery : FPS·2026
Same journal

Lip Rejuvenation Options in the Youthful Population.

Facial plastic surgery : FPS·2026
Same journal

Impact of Functional Rhinoplasty on Sleep-Disordered Breathing: A Systematic Review and Meta-Analysis.

Facial plastic surgery : FPS·2026
Same journal

The Use of Muscle-Hitch and Internal Gradual Tension Quilting Sutures for Eyebrow Lift Using an Open Temple Approach.

Facial plastic surgery : FPS·2026
See all related articles

Related Experiment Video

Updated: May 18, 2026

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
07:45

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Published on: November 6, 2018

Scars after second intention healing.

Matthew R Donaldson1, Brett M Coldiron

  • 1Department of Mohs Micrographic Surgery and Cutaneous Oncology, Mountain West Dermatology, Grand Junction, Colorado. mrdonaldson@medscape.com

Facial Plastic Surgery : FPS
|October 3, 2012
PubMed
Summary
This summary is machine-generated.

Second intention healing (SIH) offers a cost-effective, low-morbidity option for skin cancer defects. Facial location significantly impacts cosmetic outcomes, with certain areas healing better than others.

Related Experiment Videos

Last Updated: May 18, 2026

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
07:45

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Published on: November 6, 2018

Area of Science:

  • Dermatology
  • Plastic Surgery
  • Wound Healing

Background:

  • Second intention healing (SIH) is a valuable technique for managing defects after skin cancer removal.
  • It offers benefits such as reduced intraoperative morbidity and lower procedure costs.
  • SIH is associated with low rates of infection, pain, and bleeding, simplifying wound care.

Purpose of the Study:

  • To review the literature on SIH based on facial anatomy.
  • To understand how anatomical location influences cosmetic outcomes of SIH.
  • To highlight the advantages and potential complications of SIH.

Main Methods:

  • Literature review focusing on SIH and facial anatomy.
  • Categorization of facial regions into concavities (NEET), convexities (NOCH), and flat areas (FAIR).
  • Analysis of cosmetic outcomes based on defect location.

Main Results:

  • Cosmetic outcomes of SIH are highly dependent on the anatomical location of the defect.
  • Concave facial areas (e.g., medial canthus, conchal bowl) often heal imperceptibly.
  • Convex surfaces (e.g., nasal tip, malar cheek) may result in poor healing and depressed scars, while flat areas show unpredictable cosmesis.

Conclusions:

  • SIH is a viable reconstructive option after skin cancer excision, with location being a critical factor for cosmetic results.
  • Understanding facial topography (NEET, NOCH, FAIR) aids in predicting SIH outcomes.
  • Surgeons should consider SIH as part of their reconstructive algorithm, being aware of potential complications like exuberant granulation or scar distortion.