Related Experiment Video
Updated: May 18, 2026
08:20
In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
Published on: May 1, 2020
Utilizing topical therapies and mitomycin to reduce scars.
Craig Cupp1, Curtis Wesley Gaball
1Department of Otolaryngology-Head and Neck Surgery, Naval Hospital Bremerton, Bremerton, Washington, USA. Craig.cupp@med.navy.mil
Facial Plastic Surgery : FPS
|October 3, 2012
Summary
Facial plastic surgeons aim to minimize scar appearance. Techniques like Mitomycin C and silicone gel aid in controlling healing for better surgical outcomes.
Area of Science:
- Plastic surgery
- Dermatology
- Wound healing
Background:
- Minimizing scar size, width, and contour is a key objective in facial plastic surgery.
- Standard surgical techniques aim to reduce incision tension and promote healing.
Purpose of the Study:
- To explore adjunctive intraoperative and postsurgical measures for enhanced scar management.
- To highlight the utility of specific agents in controlling wound healing processes.
Main Methods:
- Review of standard surgical techniques for wound closure.
- Application of intraoperative and postsurgical measures, including Mitomycin C and silicone gel.
Main Results:
- Routine measures may not always suffice for optimal scar reduction.
- Mitomycin C and self-drying silicone gel have proven beneficial in clinical practice.
Conclusions:
- Additional measures are sometimes necessary to control the body's healing response.
- Mitomycin C and silicone gel are valuable adjuncts for improving surgical scar outcomes.
Related Concept Videos
01:19Clinical Applications of Epidermal Stem Cells
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:24Healing II: Complications
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...