Related Experiment Video
Updated: May 18, 2026

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
Published on: May 1, 2020
Utilizing topical therapies and mitomycin to reduce scars
Craig Cupp1, Curtis Wesley Gaball
1Department of Otolaryngology-Head and Neck Surgery, Naval Hospital Bremerton, Bremerton, Washington, USA. Craig.cupp@med.navy.mil
Abstract:
Minimizing scar size, width, and contour of elevation is a common goal for the facial plastic surgeon. Various standard techniques are employed to reduce tension and enhance the rapid and uneventful healing of incisions. In some cases, these routine measures are not judged to be adequate, and additional intraoperative and postsurgical measures are employed to control the body's innate healing processes. Mitomycin C and self-drying silicone gel have been particularity useful in our practice.
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