Hematogenous pyogenic spinal infection: current perceptions

As a result of reading this article, physicians should be able to:1.Understand the importance of early diagnosis and treatment of spinal infection in an effort to avoid devastating and crippling complications such as paralysis, painful deformity, and death.2.Understand current perceptions in the ongoing debate of whether operative or conventional treatment should be preferred and in which cases.3.Understand the latest advances in the surgical treatment of spinal infection, their indications, and their effectiveness.4.Understand the change in the traditionally held belief that in the presence of infection, the use of metal implants or grafts is not indicated. Controversy exists regarding optimal treatment for pyogenic spinal infection. The authors systematically reviewed peer-reviewed published clinical trials in the English language through 2009 on the clinical presentation, complications, and conservative and operative treatments of pyogenic spinal infection. The cornerstone of therapy for uncomplicated spondylodiskitis is intravenous antibiotics followed by oral antibiotics and bracing. Surgery is effective in complicated cases and improves sagittal balance, restores neurological impairment, and relieves severe pain. In cases of delayed diagnosis or surgery, potential early devastating and late crippling complications may occur. To the authors' knowledge, no Level I studies compare operative vs conservative treatment of pyogenic spinal infection.