Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

On dividing reference data into subgroups to produce separate reference ranges.

E K Harris1, J C Boyd

  • 1Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908.

Clinical Chemistry
|February 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness of different corn dried distillers grains with solubles feeding strategies and increasing the time intervals between the second Improvest dose and slaughter of immunologically castrated pigs on belly and pork fat quality.

Meat science·2017
Same author

Growth performance of immunologically castrated pigs slaughtered at 5, 7, or 9 weeks after the second Improvest dose and fed diets containing corn dried distillers grains with solubles.

Journal of animal science·2017
Same author

Effect of time interval between the second Improvest® dose and slaughter and corn dried distillers grains with solubles feeding strategies on carcass composition, primal cutout, and pork quality of immunologically castrated pigs.

Meat science·2017
Same author

Effect of Amblyomma maculatum (Acari: Ixodidae) Saliva on the Acute Cutaneous Immune Response to Rickettsia parkeri Infection in a Murine Model.

Journal of medical entomology·2016
Same author

DISTINGUISHING PHYSIOLOGIC VARIATION FROM ANALYTIC VARIATION.

Journal of chronic diseases·2015
Same author

Impact of maternal physical activity during gestation on porcine fetal, neonatal, and adolescent ovarian development.

Domestic animal endocrinology·2014
Same journal

Interlaboratory Comparison of a Glucagon and Oxyntomodulin Immuno-LC-MS/MS Assay: Implications for Diabetes Research.

Clinical chemistry·2026
Same journal

Comparison of Information-Dependent Acquisition and Sequential Window Acquisition of All Theoretical Mass Spectra for Untargeted Drug Testing on a Linear Ion Trap-Pulsing Quadrupole-Time of Flight Mass Spectrometer.

Clinical chemistry·2026
Same journal

Patterns of One-Year Change in HbA1c and Continuous Glucose Monitoring (CGM) Metrics in Older Adults with Type 2 Diabetes.

Clinical chemistry·2026
Same journal

TSH Pediatric Reference Intervals: Lack of CALIPER Applicability to US-Based Populations.

Clinical chemistry·2026
Same journal

Rapid Detection of Hemoglobinopathy Variants Using One-Step Library Preparation and Nanopore Sequencing.

Clinical chemistry·2026
Same journal

Editor's Note: Circulating Proteolytic Products of Carboxypeptidase N for Early Detection of Breast Cancer.

Clinical chemistry·2026
See all related articles

Partitioning a reference database for subpopulations offers minimal reduction in variability. However, separate reference ranges may be necessary when physiological differences justify subgrouping for accurate clinical reference limits.

Area of Science:

  • Clinical Chemistry
  • Biostatistics
  • Laboratory Medicine

Background:

  • Establishing accurate reference ranges is crucial for interpreting clinical laboratory results.
  • Subpopulation differences can influence analyte distributions, necessitating careful consideration for reference range establishment.

Purpose of the Study:

  • To evaluate statistical criteria for partitioning reference databases into subpopulations.
  • To determine the impact of partitioning on between-person variability and the accuracy of reference limits.

Main Methods:

  • Utilized general formulas relating population variances, sample sizes, and normal deviate tests.
  • Conducted simulation studies to assess the necessity of partitioning based on physiological differences.

Related Experiment Videos

Main Results:

  • Partitioning yielded minimal reduction in between-person variability, even with statistically significant mean differences.
  • Simulation studies indicated partitioning is essential when clear physiological bases exist for subgroup distinctions.

Conclusions:

  • Separate reference ranges offer limited reduction in variability but are vital when physiological differences warrant subgrouping.
  • Provided guidelines to aid decisions on establishing separate reference ranges for specific analytes.