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Genomic grade adds prognostic value in invasive lobular carcinoma
O Metzger-Filho1, S Michiels1, F Bertucci2
1Breast Cancer Translation Research Laboratory J. C. Heuson, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
Summary
Genomic grade (GG) shows superior prognostic value over histologic grade (HG) in invasive lobular carcinoma (ILC). GG improves predictions for invasive disease-free survival and overall survival in ILC patients.
Area of Science:
- Oncology
- Genomics
- Breast Cancer Research
Background:
- Histologic grade (HG) prognostic value in invasive lobular carcinoma (ILC) is uncertain, with most cases classified as HG2.
- Genomic grade (GG), a 97-gene signature, enhances HG's prognostic capability.
- This study investigates if GG can address HG limitations in ILC.
Purpose of the Study:
- To evaluate the prognostic performance of Genomic Grade (GG) in invasive lobular carcinoma (ILC).
- To determine if GG offers improved prediction of invasive disease-free survival (IDFS) and overall survival (OS) compared to HG.
- To assess GG's added prognostic value beyond traditional clinicopathologic factors.
Main Methods:
- Gene expression data from 166 frozen ILC tumor samples were analyzed.
- Genomic Grade (GG) was calculated using a 97-gene signature.
- Prognostic value was assessed using stratified Cox regression for IDFS and OS.
Main Results:
- GG classified tumors into GG low (GG1), GG high (GG3), and equivocal groups.
- Multivariate analyses revealed GG3 was significantly associated with poorer IDFS (HR 5.6, P < 0.001) and OS (HR 7.2, P = 0.01) compared to GG1.
- Median follow-up was 6.5 years.
Conclusions:
- Genomic Grade (GG) demonstrated superior prognostic performance compared to Histologic Grade (HG) in ILC.
- GG provided significant prognostic value for invasive disease-free survival and overall survival.
- GG enhanced the prognostic information from established clinicopathologic variables, including nodal status.
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