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PPARs Signaling and Cancer in the Gastrointestinal System

Valerio Pazienza1, Manlio Vinciguerra, Gianluigi Mazzoccoli

  • 1Gastroenterology Unit IRCCS "Casa Sollievo della Sofferenza" Hospital, Viale dei Cappuccini n.1, 71013 San Giovanni Rotondo, Italy.

PPAR Research
|October 3, 2012
PubMed

Insights

Peroxisome proliferators activated receptors (PPARs) have a complex role in cancer. This review explores their dual functions, examining both tumor-promoting and anti-cancer effects in gastrointestinal cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Peroxisome proliferators activated receptors (PPARs) are nuclear receptors involved in various cellular processes.
  • Their role in cancer is complex and debated, with studies showing both tumor-promoting and anti-proliferative effects.

Purpose of the Study:

  • To review the multifaceted roles of PPARs in the development and progression of gastrointestinal cancers.
  • To elucidate the controversial functions of PPARs as potential therapeutic targets in oncology.

Main Methods:

  • Literature review of studies investigating PPARs in human cancer cells and animal models.
  • Analysis of existing research on PPARs' involvement in different gastrointestinal cancer types.

Main Results:

  • PPARs exhibit context-dependent functions in gastrointestinal cancers.
  • Evidence suggests both tumor-suppressive and tumor-promoting activities of PPARs depending on the specific cancer type and cellular context.

Conclusions:

  • PPARs represent a controversial but promising area for cancer research.
  • Further investigation is needed to fully understand and potentially exploit PPARs' functions for gastrointestinal cancer prevention and therapy.

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