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Molecular recognition in allergic contact dermatitis. The concept of double-headed haptens
1Laboratoire de Dermatochimie, Université Louis Pasteur, Strasbourg, France.
Dermatologic Clinics
|January 1, 1990
Abstract:
The sensitizing capacity of double-headed haptens containing the pyrocatechol and alpha-methylene-gamma-butyrolactone groups reveals that only the pyrocatechol end is recognized as a sensitizer. Prior sensitization to the double-headed hapten provides protection against (induces immune tolerance to) further sensitization to the lactone hapten.