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Electrophysiology on Isolated Brainstem-spinal Cord Preparations from Newborn Rodents Allows Neural Respiratory Network Output Recording
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Cortico-cardio-respiratory network interactions during anesthesia.

Yuri Shiogai1, Mukesh Dhamala, Kumiko Oshima

  • 1School of Computer and Communication Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Plos One
|October 3, 2012
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Summary

General anesthetics alter brain and heart network dynamics. Different anesthetic drugs cause unique changes in network activity and connections during anesthesia.

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Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

Published on: July 23, 2020

Area of Science:

  • Neuroscience
  • Cardiovascular Physiology
  • Anesthesiology

Background:

  • General anesthetics induce reversible unconsciousness for medical procedures.
  • Understanding anesthetic effects on dynamic network interactions is crucial.

Purpose of the Study:

  • To investigate dynamic network interactions between cortical, cardiovascular, and respiratory systems during anesthesia.
  • To compare the effects of ketamine-xylazine (KX) and pentobarbital (PB) on these network dynamics.

Main Methods:

  • Applied nonparametric spectral techniques to electroencephalography (EEG), electrocardiogram (ECG), and respiratory signals.
  • Analyzed data from anesthetized rats under two different anesthetic agents.

Main Results:

  • Observed significant changes in low-frequency cortico-cardio-respiratory network interactions.
  • Found alterations in network activity strengths and the number of network links.
  • These changes varied depending on the depth of anesthesia and the specific anesthetic used.

Conclusions:

  • Anesthetic agents significantly modulate dynamic network interactions within cortico-cardio-respiratory systems.
  • The specific anesthetic employed influences the nature and extent of these network changes.
  • Network analysis provides insights into the complex effects of anesthesia on physiological systems.