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Related Experiment Videos

Growth hormone in polymethylmethacrylate cement.

S Downes1, D J Wood, A J Malcolm

  • 1University Department of Orthopaedics and Pathology, Newcastle, England.

Clinical Orthopaedics and Related Research
|March 1, 1990
PubMed
Summary

Human growth hormone (hGH) released from bone cement may enhance bone healing. Studies show hGH-loaded cement increased osteoid formation, suggesting improved bone-cement interface strength.

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Area of Science:

  • Biomaterials Science
  • Orthopedic Research
  • Tissue Engineering

Background:

  • Polymethylmethacrylate (PMMA) bone cement is widely used in orthopedic surgery.
  • The interface between bone and cement can be a site of mechanical failure.
  • Enhancing bone integration with cement is crucial for long-term implant success.

Purpose of the Study:

  • To investigate the in vitro release of human growth hormone (hGH) from PMMA bone cement.
  • To evaluate the in vivo effects of hGH-released PMMA bone cement on bone formation at the bone-cement interface in a rabbit model.

Main Methods:

  • In vitro release of hGH from PMMA bone cement was measured over 40 days using ELISA.
  • hGH-loaded PMMA and plain PMMA were implanted into the distal femurs of rabbits.

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  • Histomorphometry was performed on retrieved femurs at 1, 2, and 4 months post-implantation.

    • Main Results:

    • In vitro studies confirmed sustained release of hGH from the bone cement.
    • Histomorphometry revealed a significantly greater percentage of osteoid at the hGH-loaded cement surface compared to the control at one month.
    • Increased osteoid suggests enhanced osteogenesis and new bone formation.

    Conclusions:

    • The release of hGH from PMMA bone cement can stimulate osteogenesis.
    • This stimulation may lead to improved bone formation at the bone-cement interface.
    • hGH-loaded bone cement shows potential for enhancing the biological fixation of orthopedic implants.