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Updated: May 18, 2026
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
p53 codon 72 polymorphism and hematological cancer risk: an update meta-analysis
Yu Weng1, Liqin Lu, Guorong Yuan
1Department of Clinical Laboratory, Zhejiang Univerisity School of Medicine, Sir Run Run Shaw Hospital, Hangzhou, China.
Plos One
|October 3, 2012
Summary
The p53 Arg72Pro polymorphism is not linked to overall hematological malignancy risk. However, it may increase susceptibility to non-Hodgkin lymphomas, particularly in heterozygote and dominant models.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Conflicting evidence exists regarding the association between p53 codon 72 (Arg72Pro) polymorphism and hematological malignancies risk.
- The p53 protein plays a crucial role in tumor suppression, making its genetic variations potential factors in cancer development.
Purpose of the Study:
- To conduct a meta-analysis to clarify the effect of the p53 Arg72Pro polymorphism on the risk of developing hematological malignancies.
Main Methods:
- A comprehensive literature search was performed on PubMed up to April 2012.
- Included studies focused on p53 codon 72 polymorphism and the risk of leukemia, lymphoma, or myeloma.
- Data from 13 eligible articles, encompassing 2,731 cases and 7,356 controls, were analyzed.
Main Results:
- The overall meta-analysis found no significant association between p53 Arg72Pro polymorphism and the risk of hematological malignancies.
- Stratified analysis revealed a significantly increased risk of non-Hodgkin lymphomas in the heterozygote (Arg/Pro vs. Arg/Arg) and dominant (Arg/Pro+Pro/Pro vs. Arg/Arg) models.
- No significant association was observed between p53 Arg72Pro polymorphism and leukemia risk, even when stratified by subtypes, ethnicities, or control sources.
Conclusions:
- The p53 Arg72Pro polymorphism may contribute to the susceptibility of developing non-Hodgkin lymphomas.
- Further research is warranted to fully elucidate the role of this polymorphism in various hematological malignancies.
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