Related Experiment Video
Updated: May 18, 2026

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
Published on: July 13, 2019
The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC
Chang Kyoo Sung1, Hyungshin Yim, Hongcang Gu
1Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America.
Abstract:
p150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription. Overexpression of p150 in human ovarian surface epithelial cells leads to decreased expression, and downregulation to increased expression, of c-MYC. c-MYC is repressed upon restoration of p150 to ovarian carcinoma cells. Induction of apoptosis by etoposide results in recruitment of p150 to the c-MYC promoter and to repression of c-MYC. Analysis of data in The Cancer Genome Atlas shows negative correlations between SALL2 and c-MYC expression in four common solid tumor types.
Related Concept Videos
Abnormal Proliferation
Induced Pluripotent Stem Cells
Somatic cells are...
Master Transcription Regulators
RNA Polymerase II Accessory Proteins
Co-activators and Co-repressors
Negative Regulator Molecules
