Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methane excretion and experimental colonic carcinogenesis.

J A Flick1, S R Hamilton, F J Rosales

  • 1Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

Digestive Diseases and Sciences
|February 1, 1990
PubMed
Summary

This study investigated methane (CH4) excretion in rats during experimental colon cancer development. Results showed no association between CH4 excretion and the onset or amount of methane produced in rats with or without colon tumors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Crizotinib in patients with tumors harboring ALK or ROS1 rearrangements in the NCI-MATCH trial.

NPJ precision oncology·2022
Same author

Corrigendum to 'Ado-trastuzumab emtansine (T-DM1) in patients with HER2-amplified tumors excluding breast and gastric/gastroesophageal junction (GEJ) adenocarcinomas: results from the NCI-MATCH trial (EAY131) subprotocol Q': [Annals of Oncology 30 (2019) 1821-1830].

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Ado-trastuzumab emtansine (T-DM1) in patients with HER2-amplified tumors excluding breast and gastric/gastroesophageal junction (GEJ) adenocarcinomas: results from the NCI-MATCH trial (EAY131) subprotocol Q.

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same author

Longitudinal growth and health outcomes in nutritionally at-risk children who received long-term nutritional intervention.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2015
Same author

NZVI modified magnetic filter paper with high redox and catalytic activities for advanced water treatment technologies.

Chemical communications (Cambridge, England)·2014
Same author

Effects of oral nutritional supplementation in the management of malnutrition in hospital and post-hospital discharged patients in India: a randomised, open-label, controlled trial.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2014

Area of Science:

  • Gastroenterology
  • Oncology
  • Microbiology

Background:

  • Methane-producing gut bacteria are common, but their role in colon cancer is unclear.
  • Previous research suggests a potential link between methane and gastrointestinal conditions.

Purpose of the Study:

  • To investigate the association between methane (CH4) excretion and experimental colonic carcinogenesis.
  • To determine if CH4 production correlates with tumor development in a rat model.

Main Methods:

  • Rats were treated with azoxymethane (AOM), a colon carcinogen, or given a placebo.
  • Methane (CH4) excretion was measured throughout the study period.
  • CH4 levels were compared between carcinogen-treated and control groups, and among AOM-treated animals with and without tumors.

Related Experiment Videos

Main Results:

  • All rats, both experimental and control, eventually exhibited detectable methane (CH4) excretion by week 26.
  • No significant differences were observed in the time of onset for detectable CH4 excretion between the groups.
  • The amount of CH4 excreted did not differ between AOM-treated rats with tumors and those without, nor compared to controls.

Conclusions:

  • This study found no evidence to support a link between methane (CH4) excretion and the development of experimental colonic dysplasia or adenocarcinoma.
  • The presence or amount of methane production does not appear to be a reliable biomarker for colon carcinogenesis in this rat model.