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Related Experiment Videos

Selenium and cardiovascular surgery: an overview.

Fengwei Guo1, Nadejda Monsefi, Anton Moritz

  • 1Department of Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany.

Current Drug Safety
|October 4, 2012
PubMed
Summary

Selenium, essential for antioxidant enzymes like glutathione peroxidase (GPx), plays a role in managing oxidative stress. This review examines selenium

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Area of Science:

  • Biochemistry and Molecular Biology
  • Nutritional Science
  • Cardiovascular Surgery

Background:

  • Selenium is vital for antioxidant enzymes (GPx, TrxR) crucial for human physiology.
  • Oxidative stress, involving reactive oxygen species (ROS), is linked to diseases and surgical procedures.
  • Cardiac surgery with cardiopulmonary bypass induces oxidative stress via ischemia-reperfusion injury.

Purpose of the Study:

  • To review experimental and clinical evidence on selenium supplementation in cardiac surgery.
  • To focus on the pathophysiology of oxidative stress and selenium's role.
  • To evaluate selenium's clinical utility for perioperative cardiac surgery patients.

Main Methods:

  • Literature review of experimental and clinical studies.
  • Analysis of selenium's role in antioxidant enzyme function.
  • Examination of oxidative stress mechanisms in cardiac surgery.

Main Results:

  • Selenium is essential for GPx and TrxR, which combat oxidative stress.
  • Some evidence suggests selenium supplementation may reduce complications after cardiac surgery.
  • Clinical data on selenium's efficacy in cardiac surgery outcomes remain inconclusive.

Conclusions:

  • Selenium's antioxidant properties are significant, particularly in managing oxidative stress.
  • Further research is needed to clarify the role and optimal use of selenium in cardiac surgery.
  • Understanding selenium's impact on ischemia-reperfusion injury is critical for patient outcomes.