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Sequence and structural basis for chromosomal fragility during translocations in cancer

Vidya Gopalakrishnan1, Sathees C Raghavan

  • 1Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India.

Future Oncology (London, England)
|October 4, 2012
PubMed
Summary

Chromosomal translocations, a hallmark of cancer, are not random. Specific genomic regions are prone to breakage due to DNA sequence, structure, and nuclear positioning, influencing cancer development.

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