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Related Experiment Video

Updated: May 18, 2026

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

Published on: December 23, 2017

Three-dimensional poly(ε-caprolactone) bioactive scaffolds with controlled structural and surface properties.

A Gloria¹, F Causa, T Russo

¹Institute of Composite and Biomedical Materials, National Research Council, P.le Tecchio 80, 80125, Naples, Italy. angloria@unina.it

Biomacromolecules

|October 4, 2012

Summary

This summary is machine-generated.

This study presents 3D biodegradable scaffolds with tunable mechanical properties and bioactive surfaces for tissue engineering. Surface modification enhanced cell attachment without altering bulk mechanical performance.

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Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

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Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

Area of Science:

Biomaterials Science
Tissue Engineering
Surface Chemistry

Background:

Developing multifunctional scaffolds for tissue engineering remains a challenge.
Scaffolds need tunable structural properties and bioactive interfaces for effective tissue regeneration.

Purpose of the Study:

To create three-dimensional (3D) biodegradable polycaprolactone (PCL) scaffolds with controlled mechanical and surface properties.
To functionalize these scaffolds with RGD peptides to enhance bioactivity.
To investigate the impact of surface modification on scaffold performance.

Main Methods:

Utilized rapid prototyping (3D fiber deposition) for scaffold fabrication.
Employed surface treatment (aminolysis and peptide coupling) for functionalization.
Characterized mechanical properties (compressive modulus, hardness) using macro- and nano-indentation.
Assessed surface modification and peptide distribution via confocal microscopy and chemical analysis.

Main Results:

Achieved tunable compressive modulus (60-90 MPa) based on scaffold design.
Surface treatment preserved macromechanical behavior but reduced hardness.
Confirmed successful functionalization and bioactivation with quantified peptide presence.
Demonstrated improved NIH3T3 fibroblast adhesion, indicating effective peptide presentation.

Conclusions:

Successfully developed 3D PCL scaffolds with tailored mechanical and bioactive properties.
Surface modification is a viable strategy to enhance scaffold bioactivity for tissue engineering.
The presented methods allow for detailed analysis of scaffold functionalization and bioactivation.