Related Experiment Video
Updated: May 18, 2026
Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
Published on: October 25, 2015
Cord blood S100B levels in low-risk term pregnancies with meconium-stained amniotic fluid
Deniz Hızlı1, Sadıman Kıykaç Altınbaş, Aydın Köşüş
1Department of Obstetrics & Gynecology, Fatih University, Faculty of Medicine, Ankara, Turkey. denizhizli@yahoo.com
Objective:
The aim of this study was to compare cord blood S100B levels and cord blood gas parameters of term infants with meconium-stained amniotic fluid (MSAF) to those infants with clear amniotic fluid.
Methods:
Term pregnant women at an active phase of labor and having MSAF were defined as the study group (n = 35) and pregnant women with clear amniotic fluid, and matched for age, parity, and gestational age were defined as the control group (n = 35). Cord blood S100B levels and gas parameters were measured.
Results:
LogS100B values of study and control groups were 2.40 ± 0.21 and 2.43 ± 0.29 pg/ml, respectively. The difference was not statistically significant (p = 0.675). LogS100B levels slightly increased as meconium thickened. (2.32 ± 0.16, 2.41 ± 0.17, and 2.44 ± 0.28 pg/ml, respectively). However, no difference was found between groups (p = 0.438). Moreover, the study group had a statistically lower HCO(3) level (21.80 vs 23.60 mmol/l) and a higher rate of base deficit (4.85 vs 3.25 mmol/l) than the control group. However, median HCO(3) and base deficit values were within normal limits in both groups.
Conclusion:
The present study showed that cord blood S100B levels of infants born through MSAF were not different from those with clear amniotic fluid. This finding suggests that MSAF, regardless of its thickness, may not be related to brain damage in low risk term pregnancies.