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Updated: May 18, 2026

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
Published on: November 29, 2013
Effect of hydrogen bond interaction on protein phase transition
1High Performance Computing Centre, Nanyang Technological University, Block NS4-04-25, 50 Nanyang Avenue, 639798 Singapore.
Abstract:
We derive the grand partition function of protein chain by restricting dihedral angles to exist only in five distinct states and assume that the dominant noncovalent potential is the hydrogen bond interaction. We investigate the phase transition of protein secondary structures and the order of the transition through analyzing its heat capacity. Our theory demonstrates the presence of α-β-coil structural phase transition in the protein polyalanine.
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