Related Experiment Video
Updated: May 18, 2026
14:55
Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
Published on: April 18, 2011
Profiling motor control in spinal cord injury: moving towards individualized therapy and evidence-based care
1Spinal Cord Injury Research Program, Shepherd Center, Atlanta, GA 30309, USA. keith_tansey@shepherd.org
The Journal of Spinal Cord Medicine
|October 4, 2012
Abstract:
This article, based on the keynote address at the 5th National Spinal Cord Injury Conference in Toronto, addresses methods to neurophysiologically characterize patients after spinal cord injury and proposes how those methods could be used to individualize therapeutic interventions and monitor their efficacy over the course of neurorehabilitation.
Related Concept Videos
01:14Spinal Cord Injury ll: Pathophysiology
Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
01:25Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...