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Diabetes is associated with lower global cognitive function in schizophrenia.
Yoichiro Takayanagi1, Nicola G Cascella, Akira Sawa
1Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Schizophrenia Research
|October 4, 2012
Summary
Diabetes mellitus (DM) worsens cognitive function in schizophrenia (SZ) patients, particularly in vigilance, processing speed, and reasoning. Untreated DM in SZ patients showed poorer cognitive performance.
Area of Science:
- Neuroscience
- Psychiatry
- Metabolic Disorders
Background:
- Schizophrenia (SZ) frequently co-occurs with metabolic disorders like diabetes mellitus (DM).
- The impact of DM on cognitive dysfunction in SZ and the benefits of DM treatment remain debated.
- This study re-analyzes cognitive data from the CATIE schizophrenia trial.
Purpose of the Study:
- To investigate the effect of DM on cognitive performance in patients with schizophrenia.
- To determine if DM treatment influences cognitive function in SZ patients.
Main Methods:
- Utilized data from 1289 SZ patients from the CATIE study.
- Assessed cognitive domains (verbal memory, vigilance, processing speed, reasoning, working memory) and metabolic characteristics.
- Employed multiple linear regression and analyses of covariance to analyze the impact of DM and its treatment.
Main Results:
- Co-morbid DM in SZ was associated with worse overall cognitive performance and deficits in vigilance, processing speed, and reasoning.
- Obesity, hypertension, and dyslipidemia did not correlate with cognitive function in SZ.
- SZ patients with untreated DM exhibited poorer overall cognition and significantly lower vigilance scores compared to non-diabetic SZ patients.
Conclusions:
- Diabetes mellitus negatively impacts overall cognitive function in schizophrenia patients.
- Untreated DM exacerbates cognitive deficits, especially vigilance, in individuals with schizophrenia.
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