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Updated: May 18, 2026
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Cognitive correlates of repetitive transcranial magnetic stimulation (rTMS) in treatment-resistant depression--a
Karina K Kedzior1, Vikram Rajput, Greg Price
1School of Humanities and Social Sciences, Jacobs University Bremen, Campus Ring 1, Bremen, 28759, Germany. kkedzior@graduate.uwa.edu.au
Background:
The aim of the current study was to investigate the cognitive correlates of repetitive transcranial magnetic stimulation (rTMS) in 10 treatment-resistant depression patients.
Methods:
Patients received forty 20-min sessions of fast-frequency (10 Hz) rTMS of the left dorsolateral prefrontal cortex (DLPFC) over 20 days. Concept-shift ability (accuracy and duration of performance) was assessed daily with a Modified Concept-Shifting Task (mCST) in patients and in eight healthy volunteers. General cognitive functioning test (Repeatable Battery for the Assessment of Neuropsychological Status; RBANS), Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HAM-D) were applied before the first and after the last rTMS.
Results:
Compared to before rTMS on the first 10 days, the patients performed the mCST significantly more accurately after rTMS on the last 10 days (p < .001, partial eta squared=.78) while the same comparison in healthy volunteers was not statistically significant (p = .256, partial eta squared=.18). A significant improvement in immediate memory on RBANS and reduction in BDI and HAM-D scores were also observed after the last compared to before the first rTMS.
Conclusion:
The rTMS is associated with an improvement in selective cognitive functions that is not explained by practice effects on tasks administered repeatedly.
Trial Registration:
Name: "Repetitive Transcranial Magnetic Stimulation (rTMS) in the treatment of depression, assessed with HAM-D over a four week period."URL: www.actr.org.au
Registration Number:
ACTRN012605000145606.
