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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: May 18, 2026

Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts
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Metastatic atypical fibroxanthoma.

Elizabeth K Satter1

  • 1Naval Medical Center, San Diego, California, USA.

Dermatology Online Journal
|October 4, 2012
PubMed
Summary

A rare case of metastasizing atypical fibroxanthoma (AFX), a type of sarcoma, resulted in patient death. This study highlights key diagnostic features of this aggressive cancer.

Area of Science:

  • Dermatopathology
  • Oncology
  • Surgical Pathology

Background:

  • Atypical fibroxanthoma (AFX) is a rare soft tissue sarcoma.
  • AFX typically exhibits low-grade malignant potential with infrequent metastasis.

Observation:

  • This report details a unique case of AFX with extensive metastasis.
  • The patient's condition ultimately led to a fatal outcome.

Findings:

  • The case underscores the importance of considering AFX in the differential diagnosis of undifferentiated pleomorphic sarcomas.
  • Key clinical, immunohistochemical, and genetic markers aiding in AFX diagnosis are discussed.

Implications:

  • Accurate and timely diagnosis of AFX is crucial for patient management.

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  • Understanding the aggressive potential of AFX can inform treatment strategies and prognostication.