Calcium deposits in the perineurium and their relation to lipid accumulation

Calcification of the perineurium in sural nerves occurs in human adults. Deposits of calcium salts can be found focally in the middle and outer layers of the perineurium. Evidence indicates that this calcification is related to nerve fibre breakdown and to the local presence of lipids in the perineurium. The origin of the lipids may be senescent cells or degradation myelin.