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Updated: May 18, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Reduction of metal ions by boranephosphonate DNA
Subhadeep Roy1, Magdalena Olesiak, Petra Padar
1Department of Chemistry and Biochemistry, University of Colorado, 3415 Colorado Ave., JSC Biotech Bldg. 530, UCB 596, Boulder, CO 80309, USA.
Abstract:
Oligodeoxyribonucleotides bearing boranephosphonate linkages (bpDNA) were shown to reduce a number of metal ions and form nanoparticles through a novel reaction pathway that leads to phosphate diesters or phosphate triesters in water or alcohols respectively. The synthetic utility of this reaction was further demonstrated through the synthesis of oligodeoxyribonucleotides containing phosphate triester linkages. This new reactivity also makes bpDNA promising for use in construction of DNA templated metallic nanostructures.
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