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Updated: May 18, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Concise and efficient syntheses of preQ1 base, Q base, and (ent)-Q base
Hans-Dieter Gerber1, Gerhard Klebe
1Institut für Pharmazeutische Chemie der Philipps-Universität Marburg, Marbacher Weg 6, 35032 Marburg, Germany.
Abstract:
To thoroughly study the functional role of prokaryotic t-RNA-guanine-transglycosylases which are essential in the pathogenesis of shigellosis, novel efficient, high-yielding synthetic approaches for preQ(1) base, Q base, as well as for (ent)-Q base mainly employing cheap and readily available starting materials have been developed. Q base as well as (ent)-Q base are accessible starting from preQ(1) base via nucleophilic substitution reactions with appropriately decorated halocyclopentenyl synthons, prior to that prepared from naturally occurring carbohydrates.
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