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Algorithm for optimal linear model-based control with application to pharmacokinetic model-driven drug delivery.

J R Jacobs1

  • 1Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710.

IEEE Transactions on Bio-Medical Engineering
|January 1, 1990
PubMed
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This study presents an optimized algorithm for computer-controlled intravenous anesthetic administration. It enables flexible, practical, and analytically optimized drug infusion rates based on physician-defined plasma drug concentration setpoints.

Area of Science:

  • Pharmacology
  • Anesthesiology
  • Computer Science

Background:

  • Computerized pharmacokinetic models are used to control intravenous anesthetic drug administration.
  • Existing algorithms rely on linear pharmacokinetic models to determine infusion rates.
  • Achieving precise and adjustable drug concentrations remains a challenge.

Purpose of the Study:

  • To describe a novel algorithm for pharmacokinetic model-driven anesthetic administration.
  • To achieve flexible, practical, and analytically optimized drug infusion control.
  • To enable physicians to interactively adjust target plasma drug concentrations.

Main Methods:

  • Development of a new algorithm for intravenous anesthetic administration.
  • Utilizing a linear pharmacokinetic model to compute drug infusion rates.

Related Experiment Videos

  • Implementing interactive setpoint adjustment for physician control.

    • Main Results:

    • The algorithm successfully computes drug infusion rates based on pharmacokinetic models.
    • It allows for flexible adjustment of plasma drug concentration setpoints.
    • The system provides practical and analytically optimized drug delivery.

    Conclusions:

    • The described algorithm offers an advanced approach to computerized anesthetic management.
    • It enhances control flexibility and optimization in drug administration.
    • This method supports precise achievement and maintenance of target drug levels.