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Related Concept Videos

Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

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[Testosterone in old age: an up-date].

A Hilbert-Walter1, R Büttner, C Sieber

  • 1Klinik für Innere Medizin 2 - Geriatrie des Klinikums Nürnberg, Nürnberg.

Deutsche Medizinische Wochenschrift (1946)
|October 4, 2012
PubMed
Summary
This summary is machine-generated.

Male aging involves gradual reproductive function decline, not abrupt menopause. Late-onset hypogonadism diagnosis requires concurrent symptoms and low testosterone, but its relevance and testosterone therapy

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Area of Science:

  • Geriatric Medicine
  • Endocrinology
  • Male Reproductive Health

Context:

  • Male reproductive function declines gradually with age, unlike female menopause.
  • Aging men may be diagnosed with androgen deficiency based on conventional testosterone thresholds.
  • The role of androgen substitution in geriatric medicine is under scrutiny.

Purpose:

  • To evaluate the diagnosis and implications of late-onset hypogonadism (LOH) in aging men.
  • To clarify the relationship between low testosterone, symptoms, and mortality.
  • To assess the efficacy and risks of testosterone supplementation in older men.

Summary:

  • Late-onset hypogonadism (LOH) diagnosis necessitates concurrent testosterone deficiency symptoms and low testosterone levels.
  • Current diagnostic criteria for LOH may lead to over-diagnosis, potentially lacking significant geriatric relevance.
  • Testosterone supplementation shows limited benefits for age-related sarcopenia and carries cardiovascular risks.

Impact:

  • Highlights the need for precise LOH diagnostic criteria in geriatric populations.
  • Suggests caution regarding uncritical testosterone supplementation in aging men, especially those with cardiovascular disease.
  • Emphasizes the lack of demonstrated causality between low testosterone and mortality, questioning widespread substitution therapy.