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Moderate-intensity physical activity ameliorates the breast cancer risk in diabetic women
Gabriela Torres-Mejía1, Angélica Angeles-Llerenas, Carolina Ortega-Olvera
1Institute of Public Health, Center for Population Health Research, Cuernavaca, Morelos, Mexico.
Objective:
To evaluate the association between self-reported diabetes and the risk of breast cancer (BC) and its interaction with moderate-intensity physical activity in pre- and postmenopausal Mexican women.
Research Design And Methods:
A population-based case-control study was conducted using 1,000 incident case subjects and 1,074 control subjects. Blood samples and information on health, diet, physical activity, and anthropometric measurements were obtained.
Results:
The association between diabetes and BC risk decreased with increasing tertiles of moderate-intensity physical activity (odds ratio [OR] = 4.9 [95% CI 2.3-10.8]; 3.0 [1.3-6.9]; and 1.0 [0.1-9.2], respectively, for each tertile) (test for interaction = 0.04). Compared with the women in the lowest tertiles, increased risk was observed in those premenopausal women with the highest serum C-peptide, IGF-1, and IGF-1 binding protein 3 levels.
Conclusions:
Moderate-intensity physical activity can substantially ameliorate the increased BC risk in diabetic women.
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