Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Muscles for Facial Expressions01:14

Muscles for Facial Expressions

4.6K
The craniofacial muscles are a collection of approximately 20 thin skeletal muscles situated beneath the skin of the face and scalp. These muscles, primarily responsible for the vast array of human facial expressions, originate from the bones or fibrous structures of the skull and extend outwards to connect with the skin. While most skeletal muscles in the body are enveloped in thick fascia, facial muscles generally have a more delicate fascial covering, with the buccinator muscle being a...
4.6K
Facial Feedback Hypothesis01:24

Facial Feedback Hypothesis

521
Charles Darwin proposed that facial expressions are an evolutionary adaptation for communication. He argued that these expressions are not influenced by culture but are universal across species. For example, a snarling expression with exposed teeth signals a threat in many animals, including humans. Darwin also suggested that displaying an emotion can intensify the feeling. Smiling, for example, could enhance one's sense of happiness. This idea laid the foundation for understanding the role...
521
Cranial Bones: Lateral View01:27

Cranial Bones: Lateral View

4.3K
The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
4.3K
Evolutionary Psychology01:20

Evolutionary Psychology

879
Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the...
879
Convergent Evolution01:54

Convergent Evolution

31.3K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
31.3K
Cranial Bones: Superior and Posterior View01:14

Cranial Bones: Superior and Posterior View

4.8K
The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TrialR: critical enablers and the need for reusable Rare Disease Clinical Trial infrastructure in Western Australia.

Orphanet journal of rare diseases·2026
Same author

Translating multi-omics into healthcare: requisites for scalable and equitable implementation.

Human genomics·2026
Same author

Challenges and opportunities for the use of telehealth in rare disease diagnosis, treatment, research, and education: key opinion leader interviews by the IRDiRC telehealth task force.

Therapeutic advances in rare disease·2026
Same author

Fostering equity in precision health through diverse 3D facial data.

Frontiers in medical technology·2026
Same author

Language in rare disease: a call for systemic and empathetic action.

Lancet (London, England)·2026
Same author

Reimagining care of people living with rare diseases with artificial intelligence.

PLoS medicine·2026
Same journal

RETRACTION: "Differential Effects of AKT1(p.E17K) Expression on Human Mammary Luminal Epithelial and Myoepithelial Cells".

Human mutation·2026
Same journal

Diagnostic Yield of Genome Sequencing in an Iranian Exome-Negative Autosomal-Recessive Intellectual Disability Cohort.

Human mutation·2026
Same journal

Exploring the Functional Impact of Individual <i>DDX41</i> Variants With a Fast and Robust Cell-Based Method.

Human mutation·2026
Same journal

Modeling the Effects of Single Nucleotide Polymorphisms (SNPs) on the Structure and Function of the Human <i>RET</i> Gene: An In Silico Study.

Human mutation·2026
Same journal

Driver Mutation Subtypes Differentially Shape Immune Evasion Landscapes in Melanoma: An AI-Driven Inflammatory Pathway Model Implicating CCNE1.

Human mutation·2026
Same journal

Comment on "When the Outcome Contains the Exposure: Methodological Limits of a Genome-Wide Cross-Trait Analysis of Type 2 Diabetes and MASLD".

Human mutation·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Reverse Dissection and DiceCT Reveal Otherwise Hidden Data in the Evolution of the Primate Face
08:15

Reverse Dissection and DiceCT Reveal Otherwise Hidden Data in the Evolution of the Primate Face

Published on: January 7, 2019

7.3K

The facial evolution: looking backward and moving forward.

Gareth Baynam1, Mark Walters, Peter Claes

  • 1Genetic Services of Western Australia, Princess Margaret and King Edward Memorial Hospitals, Perth, Australia.

Human Mutation
|October 4, 2012
PubMed
Summary
This summary is machine-generated.

Three-dimensional (3D) facial analysis offers a noninvasive method for studying disease and human variation. Integrating evolutionary knowledge with 3D facial morphology can advance our understanding of health and disease.

More Related Videos

Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm
09:49

Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm

Published on: December 24, 2015

14.5K
Assessing Species-specific Contributions To Craniofacial Development Using Quail-duck Chimeras
09:38

Assessing Species-specific Contributions To Craniofacial Development Using Quail-duck Chimeras

Published on: May 31, 2014

11.3K

Related Experiment Videos

Last Updated: Jan 7, 2026

Reverse Dissection and DiceCT Reveal Otherwise Hidden Data in the Evolution of the Primate Face
08:15

Reverse Dissection and DiceCT Reveal Otherwise Hidden Data in the Evolution of the Primate Face

Published on: January 7, 2019

7.3K
Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm
09:49

Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm

Published on: December 24, 2015

14.5K
Assessing Species-specific Contributions To Craniofacial Development Using Quail-duck Chimeras
09:38

Assessing Species-specific Contributions To Craniofacial Development Using Quail-duck Chimeras

Published on: May 31, 2014

11.3K

Area of Science:

  • Biomedical research
  • Anthropology
  • Genetics

Background:

  • Three-dimensional (3D) facial analysis provides high-resolution, nonionizing, and noninvasive data for phenotypic and phenomic studies.
  • The face reflects primordial tissues and offers diagnostic clues for systemic health and various disorders.
  • Facial variation is linked to evolutionary factors and biological pathways.

Purpose of the Study:

  • To review how human evolutionary knowledge can inform the application and interpretation of 3D facial morphology studies.
  • To explore the documentation of human variation and its relationship with health and disease.
  • To propose scalable implementation strategies and future research/clinical applications for 3D facial analysis.

Main Methods:

  • Literature review integrating evolutionary biology with 3D facial analysis.
  • Analysis of existing studies on facial morphology, variation, and disease.
  • Discussion of deep phenotyping and data integration approaches.

Main Results:

  • Human evolutionary insights can enhance the interpretation of 3D facial morphology in health and disease studies.
  • 3D facial analysis is a valuable tool for high-throughput phenotyping and understanding disease.
  • Scalable implementation and future research directions are identified.

Conclusions:

  • Integrating evolutionary perspectives with 3D facial analysis deepens the understanding of human variation and disease.
  • 3D facial analysis holds significant potential for future research and clinical applications in medicine and biology.
  • This approach facilitates advances in rare and common disease research through detailed phenotyping.