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Updated: May 18, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Elective bladder preservation with multimodality treatment for bladder cancer.

A Mayadagli¹, M Kocak, O Demir

¹Department of Radiation Oncology, Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey.

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology

|October 4, 2012

Summary

Maximal transurethral resection of bladder tumor (TURBT) followed by chemotherapy and chemoradiotherapy offers a well-tolerated bladder-preserving option for medically inoperable bladder cancer patients.

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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Area of Science:

Uro-oncology
Multimodal cancer therapy

Background:

Bladder cancer management for medically inoperable patients presents significant challenges.
Transurethral resection of bladder tumor (TURBT) is a primary intervention.

Purpose of the Study:

To evaluate the efficacy and tolerability of maximal TURBT followed by induction chemotherapy and concurrent chemoradiotherapy.
To assess bladder preservation rates in patients with locally advanced bladder cancer.

Main Methods:

A cohort of 30 patients with stage T2-T4 bladder cancer received maximal TURBT.
Patients underwent 2 cycles of gemcitabine and cisplatin induction chemotherapy.
Concurrent chemoradiotherapy with gemcitabine followed induction chemotherapy.

Main Results:

Median follow-up was 28.9 months.
Radiological complete and partial response rates were 60% and 36.7%, respectively.
Cystoscopic complete and partial response rates were 40% and 30%, respectively.
One- and 2-year overall survival rates were 97.60% and 83.49%, respectively.
Median overall survival and progression-free survival were 32 and 21 months, respectively.

Conclusions:

The multimodal treatment approach was well-tolerated by patients.
This strategy achieved a high rate of bladder preservation in selected medically inoperable bladder cancer patients.