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Factors associated with early outcome in patients with large-vessel carotid strokes

Elisa Cuadrado-Godia1, Sara Jimena, Angel Ois

  • 1Neurology Department, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain. Ecuadrado@hospitaldelmar.cat

Journal of Neurology, Neurosurgery, and Psychiatry
|October 4, 2012
PubMed

Insights

Patients with symptomatic carotid stenosis often experience mild ischemic strokes but face a high risk of early neurological deterioration. Increased carotid stenosis degree significantly elevates stroke severity and deterioration risk.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Stroke Research

Background:

  • Symptomatic carotid stenosis is a significant risk factor for ischemic stroke.
  • Understanding stroke severity and early neurological deterioration (END) is crucial for patient management.
  • Carotid artery disease influences stroke outcomes.

Purpose of the Study:

  • To characterize the severity of ischemic strokes in patients with symptomatic carotid stenosis.
  • To identify the incidence of early neurological deterioration (END) in this patient group.
  • To analyze factors influencing stroke severity and END.

Main Methods:

  • An observational cohort study included 338 patients with ischemic stroke and carotid stenosis.
  • Stroke severity was categorized using the NIH Stroke Scale (NIHSS).
  • Logistic regression analyses assessed risk factors for stroke severity and END.

Main Results:

  • Most strokes (75.1%) were mild, but 23.1% of patients experienced END.
  • Higher degree of carotid stenosis, intracranial disease, and plasma glucose correlated with increased stroke severity.
  • END was independently associated with degree of carotid stenosis, prior TIA, and mean arterial pressure.

Conclusions:

  • Ischemic strokes from carotid artery disease are typically mild but have a high rate of END.
  • The degree of carotid stenosis is a key predictor of both stroke severity and END risk.
Abstract

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