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Published on: December 15, 2011
Transient glomerulonephropathy associated with primary erythrocytosis in a dog
R L Page1, M E Stiff, M C McEntee
1Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Abstract:
Proteinuria (urine protein/creatinine ratio, 13.6) resolved after control of primary erythrocytosis in a dog. Hydroxyurea and doxorubicin administration and phlebotomy were used initially to manage erythrocytosis. Remission was maintained for approximately 2 years. Glomerulonephropathy, characterized by absence of routine histologic or immunofluorescent changes and ultrastructural evidence of basement membrane deterioration and podocyte fusion, was documented. These lesions may have been a result of hypoxia and/or hyperviscosity secondary to erythrocytosis.
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