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Published on: April 21, 2021
Design and statistical optimization of osmotically driven capsule based on push-pull technology.
Wasim Shaikh1, Prashant K Deshmukh, Ganesh B Patil
1Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, India.
Pharmaceutical Development and Technology
|October 5, 2012
Summary
This study developed an osmotically active capsule using bilayer osmotic tablet technology. The optimized formulation demonstrated a strong correlation between predicted and experimental results, validating the model for drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Osmotic drug delivery systems offer controlled release profiles.
- Bilayer osmotic tablet technology provides a robust platform for drug encapsulation.
Purpose of the Study:
- To develop and statistically optimize an osmotically active capsule using bilayer (push-pull) osmotic tablet technology.
- To characterize the formulated capsules and validate the optimization model.
Main Methods:
- Formulation of an active drug layer and a push layer containing Mannitol.
- Encapsulation within a hard gelatin capsule with a semipermeable membrane coating.
- Characterization using FT-IR, DSC, SEM, and in-vitro drug release studies.
Main Results:
- The statistically optimized formulation exhibited predictable drug release behavior.
- Good correlation was observed between predicted and experimentally determined release profiles.
- Characterization confirmed the integrity and functionality of the osmotically active capsules.
Conclusions:
- The developed bilayer osmotic capsule technology is a practical approach for controlled drug delivery.
- Statistical optimization is effective in achieving desired drug release characteristics.
- The model is validated, confirming its practicability and reliability for future formulations.
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