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Osmotic Pressure

Osmotic Pressure

Osmosis is a process where solvent molecules move toward a solution through a semipermeable membrane. As the solution dilutes due to the entry of solvent, it expands. This expansion increases the hydrostatic pressure of the solution. When the hydrostatic pressure equals the osmotic pressure, osmosis stops.Osmotic pressure, denoted by Π, is the minimum pressure needed to prevent the solvent from passing into the solution by osmosis. The van 't Hoff equation calculates the osmotic pressure of an...

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A number of natural and synthetic materials exhibit selective permeation, meaning that only molecules or ions of a certain size, shape, polarity, charge, and so forth, are capable of passing through (permeating) the material. Biological cell membranes provide elegant examples of selective permeation in nature, while dialysis tubing used to remove metabolic wastes from blood is a more simplistic technological example. Regardless of how they may be fabricated, these materials are generally...

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Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure

Published on: April 21, 2021

Design and statistical optimization of osmotically driven capsule based on push-pull technology.

Wasim Shaikh¹, Prashant K Deshmukh, Ganesh B Patil

¹Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, India.

Pharmaceutical Development and Technology

|October 5, 2012

Summary

This study developed an osmotically active capsule using bilayer osmotic tablet technology. The optimized formulation demonstrated a strong correlation between predicted and experimental results, validating the model for drug delivery.

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Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems

Background:

Osmotic drug delivery systems offer controlled release profiles.
Bilayer osmotic tablet technology provides a robust platform for drug encapsulation.

Purpose of the Study:

To develop and statistically optimize an osmotically active capsule using bilayer (push-pull) osmotic tablet technology.
To characterize the formulated capsules and validate the optimization model.

Main Methods:

Formulation of an active drug layer and a push layer containing Mannitol.
Encapsulation within a hard gelatin capsule with a semipermeable membrane coating.
Characterization using FT-IR, DSC, SEM, and in-vitro drug release studies.

Main Results:

The statistically optimized formulation exhibited predictable drug release behavior.
Good correlation was observed between predicted and experimentally determined release profiles.
Characterization confirmed the integrity and functionality of the osmotically active capsules.

Conclusions:

The developed bilayer osmotic capsule technology is a practical approach for controlled drug delivery.
Statistical optimization is effective in achieving desired drug release characteristics.
The model is validated, confirming its practicability and reliability for future formulations.